Full-length IgG antibodies that specifically bind to a target molecule with high affinity have been extensively developed as research tools, as well as for diagnostic and therapeutic purposes. However, these antibodies are designed primarily to target proteins expressed on the cell-surface or on some secreted proteins. This is because antibodies usually cannot cross intact cellular or subcellular membranes in living cells due to their large size and hydrophilicity. We have developed cell penetrating antibodies, which can access the cytosol of living cells following receptor-mediated endocytosis. This unique capability will allow these next-generation therapeutic antibodies to directly target cytosolic proteins associated with many human diseases that have been previously considered untreatable.
In principle, we can engineer any therapeutic antibody with the ability to enter the cytosol.
Cell specific targeting
Our antibodies can be modified to specifically target different cell-surface receptors to enhance binding to specific tissues.
Our fully human antibodies do not require chemical conjugation or formulation for delivery. Therefore, the manufacturing procedures we would use are similar to those used for any naked therapeutic antibody.