Orum Therapeutics Announces Formation Of Scientific Advisory Board
BOSTON, US & DAEJEON, South Korea, April 4, 2022 -- Orum Therapeutics, a biotechnology company pioneering the development of tumor-directed targeted protein degraders to treat cancer, today announced the formation of its scientific advisory board (SAB). The SAB is comprised of a distinguished group of academic and industry experts who will advise the Orum Therapeutics team on the development of Orum’s novel targeted protein degraders (TPD) that use Orum’s TPD²™ approach, which combines the power of protein degradation with the precise tumor cell delivery mechanism of an antibody.
“We are proud to have experienced leaders in drug discovery and clinical development joining our SAB,” said Peter U. Park, Ph.D., Chief Scientific Officer of Orum Therapeutics. “We look forward to meeting regularly and fully leveraging the team’s diverse breadth of experiences as we progress the first molecule from our Antibody neoDegrader Conjugate platform, ORM-5029, into the clinic and continue to expand our pipeline in dual-precision protein degradation and broader protein homeostasis. With our scientific advisors’ guidance, we believe that we can bring first-in-class, dual-precision therapeutics to cancer patients quickly.”
Appointed members of the newly formed Orum Therapeutics SAB include the following:
Julie M. Cherrington Ph.D., is an experienced life science executive with extensive insight in bringing drugs into the clinic and through to commercialization. She has been a key contributor to the successful development of multiple FDA-approved products, including SUTENT®, PALLADIA®, VISTIDE®, VIREAD®, and HEPSERA®. Dr. Cherrington previously served as President and CEO of several oncology companies and currently serves on the Board of Directors for Mirati Therapeutics, Vaxart, Syncona Ltd., MycRx, Kisoji Biotechnology, and Sardona Therapeutics.
Sara Hurvitz, M.D., is Professor of Medicine at the University of California, Los Angeles (UCLA), Co-director of the Santa Monica-UCLA Outpatient Oncology Practice, Medical Director of the Clinical Research Unit of the Jonsson Comprehensive Cancer Center at UCLA, and Director of Breast Oncology. She has an active clinical practice specializing in the treatment of women with breast cancer. In addition, Dr. Hurvitz is a leader of multiple clinical trials testing new targeted therapies, including ENHERTU® for HER2 breast cancer, and preclinical evaluation of novel breast cancer targets.
Maria Koehler, M.D., Ph.D., is Chief Medical Officer of Repare Therapeutics and has more than 20 years of experience in both large, multinational pharmaceutical and biotechnology companies. Dr. Koehler served as an independent Board Member for Celyad Oncology and now serves as Board of Director for IKENA and Silverback Therapeutics. Her industry experience includes leading the development of IBRANCE®
Zoran Rankovic, Ph.D., is Director, Chemistry Centers at Jude Children’s Research Hospital. Prior to joining St. Jude, he served as director in medicinal chemistry at large pharmaceutical companies, where he led teams that delivered clinical candidates over a range of therapeutic areas. At St. Jude, Dr. Rankovic directs a multidisciplinary team that focuses on targeted protein degradation. He has published over 90 scientific papers, patents, and book chapters on drug discovery topics.
Roland B. Walter, M.D., Ph.D., M.S., is Professor at the Fred Hutchinson Cancer Center and a Professor of Medicine at the University of Washington. Dr. Walter specializes in treating acute myeloid leukemia (AML). His research seeks to develop new and improved antibody-based therapies in the laboratory that effectively kill AML cells, including treatments that eradicate the AML stem cells, and then to bring these therapies to patients.
About Orum Therapeutics
Orum Therapeutics is pioneering the development of tumor-directed targeted protein degraders by leveraging its TPD²™ approach to provide dual precision, antibody-enabled targeted protein degraders for cell-specific delivery. The Company’s proprietary platforms generated using the TPD² approach includes the Antibody neoDegrader Conjugate (AnDC™) platform, which generates first-in-class antibody drug conjugates. The first therapeutic candidates from the AnDC platform are in development for the treatment of solid tumors and hematologic cancers. Orum is located in Cambridge, Massachusetts, and Daejeon, South Korea. For more information, visit www.orumrx.com.
Contacts
Corporate: Kyuri Kim Ph.D., Senior Manager, Business Development, Orum Therapeutics, contact@orumrx.com
Media: Jessica Yingling, Ph.D., President, Little Dog Communications Inc., +1-858-344-8091, jessica@litldog.com
Forward-looking Statements
This press release contains forward-looking statements that are based on the current expectations and beliefs of Orum Therapeutics, Inc. (“Orum”). Statements in this release regarding matters that are not historical facts, including, but not limited to, statements relating to the successful development and clinical benefits of novel targeted protein degraders, the frequency of SAB meetings, the commencement of first-in-human studies, the potential for development of other product candidates, the speed with which such candidates are brought to market, and the preferability of Orum products to others available are forward looking statements. These forward-looking statements are based on management’s expectations and assumptions as of the date of this release and are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those expressed or implied by such statements. These risks and uncertainties include, without limitation, the uncertain and continually changing impacts and expected duration of the COVID-19 pandemic; the uncertainty of success in research and development activities; risks related to clinical trials, including potential delays, safety issues, or negative results; competition from alternative therapies; the risk that Orum may not be able to maintain and enforce its intellectual property; the risk that product candidates may not be successfully commercialized or adopted; the availability of financing; and risks related to the recruitment and retention of key employees, fluctuating markets and economic conditions, health care reform, prices, and reimbursement rates. The forward-looking statements in this presentation speak only as of the date of this release, and Orum undertakes no obligation to update or revise any of the statements. Orum cautions investors not to place considerable reliance on the forward-looking statements contained in this release.
Orum Therapeutics To Present Preclinical Data For ORM-5029, A Novel Antibody Neodegrader Conjugate, At The AACR Annual Meeting 2022
BOSTON & DAEJEON, South Korea, March 08, 2022--Orum Therapeutics, a biotechnology company pioneering the development of tumor-directed targeted protein degraders, today announced that the Company will present preclinical data for ORM-5029 at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2022 taking place April 8-13 virtually and in-person at the Ernest N. Morial Convention Center in New Orleans. Orum is developing ORM-5029 as a potential first-in-class targeted protein degrader therapy for HER2-expressing breast cancer.
Presentation Details
Poster Title: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer
Date and Time: Wednesday, April 13, 9:00 AM - 12:30 PM EDT
Virtual E-Poster Viewing: April 8 to July 13
Session Category: Experimental and Molecular Therapeutics
Session Title: Emerging New Anticancer Agents
Session Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 22
Poster Board Number: 7
Abstract number: 3933
About Orum’s AnDC Platform
Orum’s Antibody neoDegrader Conjugate (AnDC) platform is built on novel targeted protein degrader (TPD) combined with the precise tumor cell delivery mechanisms of antibodies to generate innovative, first-in-class cell-specific TPD for the treatment of cancer. The company has developed new molecular glue degrader payloads to specifically degrade an intracellular target protein within cancer cells via the E3 ubiquitin ligase pathway. Conjugated to antibodies, neoDegraders are designed to be delivered specifically to cancer cells and degrade the intracellular target protein and cause tumor cell death.
About Orum Therapeutics
Orum Therapeutics is pioneering the development of tumor-directed targeted protein degraders by leveraging its TPD²™ approach to provide dual precision, antibody-enabled targeted protein degraders for cell-specific delivery. The Company’s proprietary platforms generated using the TPD² approach includes the Antibody neoDegrader Conjugate (AnDC™) platform, which generates first-in-class antibody drug conjugates. The first therapeutic candidates from the AnDC platform are in development for the treatment of solid tumors and hematologic cancers. Orum is located in Cambridge, Massachusetts, and Daejeon, South Korea.
Orum Therapeutics Closes $84 Million Series B Financing To Advance Novel Targeted Protein Degrader Payloads Into Clinical Trials For Cancer
Orum’s Antibody neoDegrader Conjugate (AnDC™) platform creates ADC therapeutics to deliver a class of novel payloads specifically to cancer cells
Proprietary payloads, neoDegraders, are designed to target cancer-driving proteins for degradation via the E3 ubiquitin ligase pathway
Orum plans to use the proceeds to advance the company’s lead therapeutic candidates, ORM-5029 for solid tumors and ORM-6151 for hematological cancers, into the clinic and continue to advance R&D on its platforms and additional product candidates
June 23, 2021 07:00 AM Eastern Daylight Time
BOSTON & DAEJEON, South Korea--Orum Therapeutics, a biotech company pioneering the development of targeted protein degraders to treat cancer, today announced the close of a $84 million Series B financing. This includes a previously announced $30 million financing and $54 million in new funds led by IMM Investment and joined by new investors (KDB Investment and Atinum, among others) and existing investors (Intervest and KB Investment, among others). Orum plans to use the proceeds to advance the Company’s lead therapeutic candidates into clinical trials, explore additional payload chemistries to develop additional payloads that modulate the ubiquitin pathway, and other general corporate purposes.
Orum’s Antibody neoDegrader Conjugate (AnDC) platform is built on novel targeted protein degrader payloads combined with the precise tumor cell delivery mechanisms of antibodies to generate innovative, first-in-class antibody drug conjugates (ADCs) for the treatment of cancer. The company has developed a new class of ADC payloads, called neoDegraders, to specifically degrade intracellular target proteins within cancer cells via the E3 ubiquitin ligase pathway. Conjugated to antibodies, neoDegraders are designed to be delivered specifically to cancer cells and degrade the intracellular target protein and cause tumor cell death.
“AnDCs leverage the strengths of both targeted protein degraders and ADCs while overcoming the limitations of each modality. Advances in ADC therapies have been hampered by a lack of diversity in payloads with a novel mechanism of action to inhibit tumor cell growth, and small molecule degraders do not possess tissue specificity," said Peter U. Park, Ph.D., Chief Scientific Officer of Orum Therapeutics. “The team at Orum has created a unique set of payloads that can target intracellular proteins for degradation. These first-in-class targeted ADC protein degraders have the potential to deliver precise and catalytic tumor-killing action to improve cancer treatment.”
The lead therapeutic programs from Orum’s AnDC platform are ORM-5029 for the treatment of solid tumors and ORM-6151 for the treatment of hematological cancers. Each program employs a different antibody drug to specifically deliver Orum’s lead neoDegrader to tumor cells. The company plans to file Investigational New Drug (IND) applications for ORM-5029 and ORM-6151 in 2022 and 2023, respectively.
“We are grateful for the support of our new and returning investors as we continued to pursue our mission of developing new therapeutics to target ‘undruggable’ proteins and help patients with limited treatment options,” said Sung Joo Lee, Ph.D., Founder and CEO of Orum Therapeutics. “We believe our AnDC platform overcomes the lack of diversity in ADC payloads and the limitations of current targeted protein degrader technologies. With encouraging preclinical data on our two lead therapeutic candidates, we are excited to use the proceeds to continue to advance our first-in-class tumor-directed targeted protein degraders into the clinic for the treatment of cancer.”
About Orum Therapeutics
Orum Therapeutics is pioneering the development of tumor-directed targeted protein degraders to improve the treatment of cancer. The company’s neoDegraders are novel, proprietary payloads for targeted protein degradation and its Antibody neoDegrader Conjugate (AnDC) platform generates first-in-class antibody drug conjugates. The first therapeutic candidates from the AnDC platform are in development for the treatment of solid tumors and hematologic cancers. Orum is located in Cambridge, Massachusetts, U.S., and Daejeon, Korea. For more information, visit www.orumrx.com.